Evaluation of Anti-inflammatory Effect of Topical Serratiopeptidase in Mice

Abstract

Proteolysis enzyme therapy plays a key role in treating a wide range of nutritional and genetic diseases. Serratiopeptidase is a proteolytic enzyme with pain-relieving and anti-inflammatory effects. It is applied topically to guarantee that the enzyme reaches the therapeutic activity. A total of fifteen healthy adult male white mice were used in this study. They were divided into three groups. All mice have injected a formalin to induce edema in the mouse paw. The first group was left untreated control; the second and third groups were applied 1 and 2 percent serratiopeptidase ointment, respectively, topically to the mouse’s right-hand paw.