Evaluation the effect of amitriptyline and/or ashwagandha on body weight in male rats Ghada A.

Abstract

study aims to examine and compare the effects of amitriptyline and ashwagandha on body weight in male rats by measurement weight for 4 weeks after their exposure to these two compound. Materials and Methods: This study used twenty healthy adult male albino rats that were 8-10 weeks old and weighed 200-250g. The animals were randomly divided to 4 groups (n= 5 /group), Group 1: were served as a control group received distilled water orally (1.0ml/kg) group 2: were administered amitriptyline (10mg/kg/ orally) group 3: were administered (200mg/kg) of ashwagandha root extract and group 4: were co-administered amitriptyline (10mg/kg) and ashwagandha (200mg/kg). After 30 days of administration, The body weight was measured every week starting from the first day of administration to last week of experimental for all rats. Results: According to the one-way analysis of variance(ANOVA) showed significant differences in growth value in the co-administered Amitriptyline and ashwagandha group ( 1.48±0.09) significantly increased in comparison with control group (1.27 ± 0.04) at week 4, otherwise, there is no significant differences in growth among groups at other periods at p value ≤0.05. Conclusion: Amitriptyline induced oxidative stress causing increased in body weight during experimental periods. Administration ashwagandha alone non-significant effect on body weight but when co-administration with amitriptyline significantly increase in body weight.